Fact Checked by Doctor NameEndocannabinoids are cannabinoids naturally generated within the human body.
They play key signaling roles that help maintain homeostasis and health.
What are Endocannabinoids?
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The body’s enzymes create endocannabinoids on demand.
Two highly understood endocannabinoids are:
- Anandamide – Named after the Sanskrit word for bliss, anandamide influences pleasure, motivation, and appetite.
- 2-AG—A brain-dominant endocannabinoid that regulates inflammation and immune system signaling.
These endocannabinoids are synthesized from cell membrane fat precursors. Not stored long-term. In response to cell signals, endocannabinoid synthesis rises on demand.
What Do Endocannabinoids Do?
Endocannabinoids control several biological systems. Neurotransmitters help cells interact and convey instructions.
Endocannabinoids affect main functions:
- Appetite – Signals like anandamide regulate feelings of hunger and satiety.
- Pain perception – Endocannabinoids modulate pain response signals in the nervous system.
- Mood – Anandamide influences mood and motivation levels in the brain.
- Inflammation – 2-AG helps control inflammation levels throughout the body.
- Hormones – Endocannabinoids impact fertility, libido, and metabolism.
- Sleep – Cycles of endocannabinoid production influence sleep and wakefulness.
- Immune function – 2-AG regulates immune cell activation and cytokine production.
- Stress response – Endocannabinoids buffer the effects of excessive stress.
Comparison of Endo- and Phytocannabinoids
The body produces endocannabinoids, whereas cannabis extracts phytocannabinoids.
Cannabis contains CBD and THC. Medical marijuana’s cannabinoids alter the endocannabinoid system.
Their regulatory features boost endocannabinoids.
