Fact Checked by Doctor NameA complex system of enzymes, endocannabinoids, and signaling receptors controls human existence.
How does the Endocannabinoid System Work?
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The main components of the endocannabinoid system (ECS) include:
- Anandamide and 2-AG are human endocannabinoids.
- The CB1 and CB2 receptor proteins on the outside of cells bind to endogenous cannabis.
- Metabolic enzymes break down endocannabinoids, which are used to stop signals.
This system operates like a complex communications network spread across all tissues and organs. Endocannabinoids act as messaging molecules that cells synthesize and release when needed. They travel to locate and activate cannabinoid receptors, triggering cellular changes and responses.
What Does the ECS Do?
The ECS helps achieve homeostasis – stable internal equilibrium – in the following bodily systems:
- Appetite
- Metabolism
- Pain response
- Mood
- Hormones
- Gastrointestinal
- Immune function
- Motivation
- Pleasure and reward
- Reproduction
- Memory
- Sleep cycles
The ECS works constantly to optimize these systems. Imbalances may arise when cell signaling is disrupted, often leading to disease symptoms emerging.
Cannabis and the ECS
Compounds from the cannabis plant (like THC and CBD) can mimic endocannabinoids and interact with cannabinoid receptors when consumed.
This allows cannabis medicine to supplement and influence the ECS. Relieving ECS deficiencies may account for cannabis benefits in conditions like chronic pain, poor appetite, anxiety, and insomnia.
